Transcriptional slippage controls production of type III secretion apparatus components in Shigella flexneri
نویسندگان
چکیده
منابع مشابه
IpaD is localized at the tip of the Shigella flexneri type III secretion apparatus.
Type III secretion (T3S) systems are used by numerous Gram-negative pathogenic bacteria to inject virulence proteins into animal and plant host cells. The core of the T3S apparatus, known as the needle complex, is composed of a basal body transversing both bacterial membranes and a needle protruding above the bacterial surface. In Shigella flexneri, IpaD is required to inhibit the activity of t...
متن کاملLiposomes recruit IpaC to the Shigella flexneri type III secretion apparatus needle as a final step in secretion induction.
Shigella flexneri contact with enterocytes induces a burst of protein secretion via its type III secretion apparatus (TTSA) as an initial step in cellular invasion. We have previously reported that IpaD is positioned at the TTSA needle tip (M. Espina et al., Infect. Immuno. 74:4391-4400, 2006). From this position, IpaD senses small molecules in the environment to control the presentation of Ipa...
متن کاملHelical structure of the needle of the type III secretion system of Shigella flexneri.
Gram-negative bacteria commonly interact with animal and plant hosts using type III secretion systems (TTSSs) for translocation of proteins into eukaryotic cells during infection. 10 of the 25 TTSS-encoding genes are homologous to components of the bacterial flagellar basal body, which the TTSS needle complex morphologically resembles. This indicates a common ancestry, although no TTSS sequence...
متن کاملA Substrate-Fusion Protein Is Trapped inside the Type III Secretion System Channel in Shigella flexneri
The Type III Secretion System (T3SS) is a macromolecular complex used by Gram-negative bacteria to secrete effector proteins from the cytoplasm across the bacterial envelope in a single step. For many pathogens, the T3SS is an essential virulence factor that enables the bacteria to interact with and manipulate their respective host. A characteristic structural feature of the T3SS is the needle ...
متن کاملVisualization of the type III secretion sorting platform of Shigella flexneri.
Bacterial type III secretion machines are widely used to inject virulence proteins into eukaryotic host cells. These secretion machines are evolutionarily related to bacterial flagella and consist of a large cytoplasmic complex, a transmembrane basal body, and an extracellular needle. The cytoplasmic complex forms a sorting platform essential for effector selection and needle assembly, but it r...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2006
ISSN: 0950-382X,1365-2958
DOI: 10.1111/j.1365-2958.2006.05456.x